NORSU Guihulngan Campus is formerly known as Guihulngan Vocational High School in 1958. It is composed of six colleges offering the following courses: Associate in Computer Science, Bachelor of Science in Computer Science, Associate in Secretarial Science, Associate in Hospitality Management, Bachelor of Science in Hospitality Management, Bachelor of Science in Business Administration, Bachelor of Science in Office Systems Management, Bachelor of Elementary Education, Bachelor of Secondary Education, Midwifery, Associate in Medical, Dental, and Nursing Assistant, Associate in Industrial Technology, Bachelor of Science in Industrial Technology, Associate in Criminology, Bachelor of Science in Criminology, Bachelor of Science in Agriculture.

Negros Oriental State University, Guihulngan Campus began as the Guihulngan Vocational High School established by virtue of Republic Act 1854 on June 22, 1957. The school started on November 12, 1958, more than a year after the passage of the law, in the dilapidated grandstand of Guihulngan Elementary School, with sixty-six (66) pioneering students and five (5) eminent teachers who accepted the challenge of practicing the noblest profession in the most humble manner possible (Antiquando, personal communication, 2019; Antiquando, 1993). Three years after, the classes were recited on the present site, and the school graduated her first batch in 1962 with fourteen (14) survivors of the pioneering batch (Antiquando, personal communication, 2019; Antiquando, 1993). To expand the school and address the need for education in the municipality and the neighboring towns, Mr. Fausto D. Aragones, Principal, Guihulngan Vocational High School, worked closely with the Municipal Officials for the offering of two-year technical courses. The dream became a reality in 1974 when the college department opened its technical courses.

Almost simultaneously with Guihulngan Vocational High School, Republic Act No. 1579 was approved on June 16, 1956. The Negros Oriental Trade School then converted into the East Visayan School of Arts and Trades (EVSAT) in Dumaguete City. The conversion of the NOTS into EVSAT fast-tracked the offering of technical courses in Guihulngan Campus. In 1961, three other government schools in Negros Oriental were placed under the administration and supervision of EVSAT. One of which is Guihulngan Vocational High School in the municipality of Guihulngan, Negros Oriental National Agricultural School (NONAS) in Bayawan, and Bais School of Fisheries in Bais City. The supervision of EVSAT Dumaguete over Guihulngan Vocational High School concerning its course offerings paved the way for more educational opportunities. The programs are the four-year degree programs, the Bachelor of Science in Industrial Education in 1981 (Antiquando, personal communication, 2019; Antiquando, 1993) though it was already offered in EVSAT Dumaguete City upon the approval of Republic Act 4401 on June 19, 1965.

Guihulngan Vocational High School had gone through time and has evolved from a Vocational High School into a state college on June 10, 1983, when President Ferdinand E. Marcos signed into law Batas Pambansa No. 401. It resulted in the merger of three government academic institutions in Negros Oriental, namely the East Visayan School of Arts and Trades in Dumaguete City, the Bais School of Fisheries in Okiot, Bais City, and the Guihulngan Vocational School in Guihulngan, Negros Oriental, into one single academic entity the Central Visayas Polytechnic College (CVPC). Guihulngan Campus continued its growth for several decades, serving the people of Guihulngan.

As early as October 21, 1998, there was already an attempt from the municipal council to convert Central Visayas Polytechnic College (CVPC) into Central Visayas State University (CEVSU), authored by Honorable Joselito V. Paras and sponsored by The Committee on Education, Health and Social Service. It is stipulated in the resolution that the conversion of the state college into a state university will immensely benefit the constituents, particularly those who cannot afford to acquire tertiary education from other reputable institutions. Since it has steadfastly made quality education accessible to poor and deserving students, ensuring a better and brighter future for them (Resolution no. 98-111, s. 1991), sent to Dr. Henry A. Sojor, President of Central Visayas Polytechnic College. This resolution never came into reality for unknown reasons.

The dream of converting the state college to a university became one of the zeal of the last President of CVPC. Honorable Henry A. Sojor, Ph. D., gave his ideas and own aspirations why the state college should be converted into a university (Sibala, 2012), as cited in Valencia and Real (2015). Congressman Herminio Teves and Senator Sergio Osmea sponsored House Bill 5633 and Senate Bill 257 in the twelfth legislature, which officially passed on June 10, 2004, and signed by Senate President Franklin Drilon and House Speaker Jose De Venecia (Sojor, 2004 as cited in Valencia & Real, 2015).

On June 25, 2004, her Excellency President Gloria M. Arroyo signed them the bill into law, now Republic Act 9299, entitled, " An Act Converting Central Visayas Polytechnic College (CVPC) into a State University to be known as Negros Oriental State University (NORSU) integrating therewith the Genaro Goñi memorial college in the city of Bais, the Siaton community college in the Municipality of Siaton, and the Mabinay Institute of Technology in the Municipality of Mabinay, all located in the province of Negros Oriental and appropriating funds therefore. Central Visayas Polytechnic College-Guihulngan Campus being a State College is now converted into a State University.